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Association of physical activity and sleep duration with risk of mortality: a population-based cohort study using accelerometry

Physical activity (PA) and sleep are two core lifestyle components occupying the 24-h life cycle. Adherence to sufficient PA and healthy sleep is essential for prolonging life expectancy.

Prospective cohort study was published online in European Journal of Preventive Cardiology.

A 7-day accelerometer recording was performed on 92 221 participants (age 62.4 ± 7.8 years; 56.4% women) from the UK Biobank. Sleep duration was further divided into three groups: short (<6 h/day), normal (6–8 h/day), and long sleep duration (>8 h/day).

All participants was divided total volume of PA into three levels according to tertiles (high, intermediate, low), and moderate-to-vigorous PA (MVPA) into two groups based on the World Health Organization guidelines (≥150 min of moderate intensity PA, or ≥75 min of vigorous intensity PA, or equivalent combinations of both throughout the week). The mortality outcomes were prospectively collected through the death registry.

Over a median follow-up of 7.0 years, 3080 adults died, of which 1074 died from cardiovascular disease (CVD) and 1871 from cancer. The associations of PA and sleep duration with mortality risk were all in a curvilinear dose–response pattern (Pnonlinearity <0.001). PA and sleep duration had additive and multiplicative interactions on mortality risk (Pinteraction <0.05). Compared with the participants with guideline-recommended MVPA and normal sleep duration, those without recommended MVPA but having short or long sleep duration were at a higher risk for all-cause mortality [short sleep: hazard ratio (HR) = 1.88; 95% confidence interval (CI), 1.61–2.20; long sleep: HR = 1.69; 95% CI, 1.49–1.90]. A higher volume of PA or recommended MVPA attenuated the detrimental effects of short or long sleep duration on all-cause and CVD mortality risks.

MVPA meeting recommendations or a higher volume of PA at any intensity potentially diminished the adverse effects on all-cause and cause-specific mortality associated with short and long sleep duration.

https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwad060/7086191

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