Disorders which disrupt consolidated sleep, such as short sleep, have been associated with cardiovascular disease in general and coronary artery disease in particular. However, there is not enough studies to positive association between sleep duration and peripheral artery disease (PAD) risk.
The study was published 16 March 2023 in the European Heart Journal Open. This is an analysis of two large cohort studies (more than 500,000 participants), one case-control study (which included 28,123 participants with peripheral atherosclerosis and 128,459 people in the control group) and UK Biobank data (452,028 individuals). The analysis of these studies, as well as the Mendeleev pseudorandomization, made it possible to demonstrate that short sleep duration was associated with an increased risk of PAD.
Observational analyses demonstrated a U-shaped association between sleep duration and PAD risk. Incident PAD risk was higher in those with short sleep [<5 h; hazard ratio (HR) 1.74; 95% confidence interval (CI) 1.31–2.31] or long sleep (≥8 h; HR 1.24; 95% CI 1.08–1.43), compared to individuals with a sleep duration of 7 to <8 h/night. Observational analysis also revealed positive associations between daytime napping (HR 1.32, 95% CI 1.18–1.49) with PAD. MR analysis supported an inverse association between sleep duration [odds ratio (OR) per hour increase: 0.79, 95% CI, 0.55, 0.89] and PAD and an association between short sleep and increased PAD (OR 1.20, 95% CI, 1.04–1.38).
