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High Dietary protein intake is associated with kidney function decline

Daily consumption of more than 1.2 g/kg of ideal body weight of protein compared to consumption of less than 0.8 g/kg of protein is associated with a 2-fold faster annual decline of glomerular filtration rate (GFR) ( -1.60 vs. - 0.84 ml/min/1.73m2, respectively) in post-MI patients. At the same time, a daily increase in total protein intake by 0.1 g/kg of ideal body weight is associated with an additional annual GFR decline (-0.12 CI (-0.19 to -0.04) ml/min/1.73 m2) and was similar for animal and plant protein.   

     The study included a total of 2248 post-MI patients, aged 60-80 years (Alpha Omega Cohort). The actual diet was evaluated using a validated frequency questionnaire on 203 points. The average amount of protein in the diet (M±SD) was 71±19 g/day (2/3 of animal and 1/3 of plant origin). GFR was assessed at baseline and after 41 months using an equation including serum cystatin C and creatinine concentrations.

Sourse:

  1. https://www.medscape.com/viewarticle/921877#vp_1
  2. https://academic.oup.com/

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