Projects

RECOVERY: Early Surgery Best in Severe Asymptomatic Aortic Stenosis?

According to the findings of the RECOVERY study (Randomized Comparison of Early Surgery versus Conventional Treatment in Very Severe Aortic Stenosis), early surgical replacement of the aortic valve significantly reduced the risk of operative and cardiovascular mortality compared to the group of patients undergoing conservative therapy, and also found a decrease in mortality from any cause in patients with asymptomatic aortic stenosis of a very severe degree.

This randomized trial involved 145 patients with an average age of 64 years. Aortic stenosis was caused by a bicuspid aortic valve (AK) in 88 patients (61%), a degenerative change in AK in 48 patients (33%), and rheumatic AK disease in 9 patients (6%). The primary endpoint was mortality during or within 30 days after surgery (operative mortality) or death from cardiovascular causes during follow-up. The primary secondary endpoint was death from any cause.

However, further research is needed in other cohorts of patients (old age, the presence of concomitant diseases, mainly a different etiology of AK lesions, etc.).

The results of the study were published on November 16, 2019 in the New England Journal of Medicine.

https://www.medscape.com/viewarticle/921544

Back to the list