Sugary drinks consumption has increased worldwide in recent years, while evidence demonstrating their detrimental impact on cardio-metabolic health is accumulating. Artificially sweetened beverages (ASB) are marketed as a healthier alternative, but their cardiometabolic impact is debated. A large prospective cohort study (the French NutriNet-Sante cohort) investi- gated the relationships between the consumption of sugary drinks, ASB, and the risk of cardiovascular disease (CVD). Online questionnaires (examining physical activity, socioeconomic status, anthropometry) were regularly administered to participants. Every 6 months, participants are asked to fill out validated web-based 24-h dietary records. The present study focused on first incident cases of stroke, transient ischemic attack, myocardial infarction, acute coronary syndrome, and angioplasty. For all major health events reported by participants were validated based on their medical records. Data were also linked to the national health insurance system (SNIIRAM) and to the French national mortality registry (CépiDC).
A total of 104,760 participants were included in the study (mean baseline age was 42.9 ±14.6 years). During follow-up (2009 to 2019), 1,379 first incident cases of CVD occurred. Compared with non-consumers, higher consumers of sugary drinks and ASB had higher risks of first incident CVD (hazard ratio: 1.20; 95% confidence interval: 1.04 to 1.40; p for trend = 0.009) and (hazard ratio: 1.32; 95% confidence interval: 1.00 to 1.73; p for trend = 0.03), respectively. These data suggesting that ASB might not be a healthy substitute for sugary drinks, and large-scale prospective cohorts and mechanistic investigations are needed.
Источник: Journal of the American College of Cardiology. Volume 76, Issue 18, 3 November 2020
