Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. Yonggu Lee, Sung Joo Cha et al. aimed to evaluate this relationship in the nondiabetic Asian population.
Between 2001–2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014.
The non-linear relationship between HOMA-IR and the risk of AF was evaluated using a multivariate Cox proportional hazard model with a restrictive cubic spline fit.
Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14–2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1–2.5, and then plateaued afterwards (p = 0.031).
There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population.
Источник:
European Journal of Preventive Cardiology, Vol. 27(18) 1934–1941, March 2, 2020
https://journals.sagepub.com/doi/full/10.1177/2047487320908706
